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Michael D. Litt Ph.D.

Associate Professor
Medical Genetics 


Research Interests

During cellular differentiation and development the expression patterns of genes undergo significant changes.  Many of these changes which are unique for a cell type are inherited in all proceeding generations of cells.  The principle molecular mechanisms for maintaining these unique gene expression patterns during cellular differentiation are epigenetic modifications.  Consequentially deciphering the changes in epigenetic modifications during development should improve our understanding of the mechanisms involved in the development of an organism, allowing us to develop better medicines to treat diseases.  My research focuses on examining specific epigenetic marks in cell lines and tissues at different stages of development. 

 

Representative publications:

 1    Litt, M.D., Qiu, Y., and Huang, S., Histone arginine methylation: their roles in dynamic and transcriptional regulation.  Biosci. Rep. (2009)/29/131-141 Abstract

 2    Huang S., Litt, M.D., and Felsenfeld, G. - Methylation of histone H4 by arginine methyltransferase PRMT1 is essential in vivo for many subsequent histone modifications. Genes Dev. 2005 Aug 15;19(16):1885-93. | Abstract | Full Text | PDF-472K |

 3    Felsenfeld G, Burgess-Beusse B, Farrell C, Gaszner M, Ghirlando R, Huang S, Jin C, Litt M, Magdinier F, Mutskov V, Nakatani Y, Tagami H, West A, Yusufzai T.  Chromatin boundaries and chromatin domains.  Cold Spring Harb Symp Quant Biol. 2004;69:245-50. Review  (Note the date on this article reflects the date of the meeting and not the date of the publication which was not printed until August 2005) Abstract | Full Text

 4    West, A.G., Huang S., Gaszner, M., Litt, M.D., and Felsenfeld, G. - Recruitment of histone modifications by USF proteins at a vertebrate barrier element.  Mol Cell. 2004 Nov 5;16(3):453-63. Abstract