Raymond C. Beeler Professor of Radiology Director, IU Center for Neuroimaging Department of Radiology, Indiana University School of Medicine Email: Andrew Saykin, Psy.D., ABCN PubMed

Dr. Saykin joined the Indiana University School of Medicine faculty in November 2006 as director of a new transdisciplinary center of excellence in neuroimaging. The goals of the center are: 1) to utilize imaging technologies to advance the understanding of brain function and anatomy in healthy and clinical populations and though translational studies of animal models; 2) to investigate the relationship between genetic variation and phenotypic expression structurally and functionally in health, illness, and following treatment; 3) to provide training and experience in advanced brain imaging research methods; and 4) to develop, assess, and validate emerging technologies that optimize the use of molecular and functional imaging methodologies including PET, fMRI, DTI, MRS, perfusion and morphometry as well as image analysis strategies and bioinformatics.

Dr. Saykin's own NIH and foundation sponsored research program focuses on the use of brain imaging and genomic methods to study mechanisms of memory dysfunction and treatment response in neurological and psychiatric disorders. Current projects examine advanced imaging methods for early preclinical detection of Alzheimer's disease (NIA R01 AG19771), the neural basis of cancer chemotherapy-induced cognitive changes (NCI R01 CA101318), and alterations in brain activity and connectivity in schizophrenia (U54 EB005149). Each project includes a component examining genomic correlates of brain imaging phenotypic markers.

Education/Training

Graduate: Hahnemann Medical College, Philadelphia, PA
Post-Doctoral Fellowship: University of Pennsylvania, Philadelphia, PA 

Selected Publications

1. Saykin AJ, Wishart HA, Rabin LA, Santulli RB, Flashman LA, West JD, et al. Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology 2006; 67:834-842. 
2. McAllister TW, Flashman LA, McDonald BC, Saykin AJ. Mechanisms of cognitive dysfunction after mild and moderate TBI (MTBI): Evidence from functional MRI and neurogenetics. J Neurotrauma. 2006; 23(10):1450-1467. 
3. Duhaime AC, Saykin AJ, McDonald BC, et al. (2006). Functional magnetic resonance imaging of the primary somatosensory cortex in piglets. J Neurosurgery; 104:259-264. 
4. Wishart, H. A., Saykin, A. J., Rabin, L. A., et al. (2006). Increased prefrontal activation during working memory in cognitively intact APOE E4 carriers. American Journal of Psychiatry, 163(9):1603-1610. 
5. Roth RM, Saykin AJ, Flashman LA, Pixley HS, West JD. Event-related fMRI of response inhibition in Obsessive-Compulsive disorder. Biological Psychiatry (2007, in press) 
6. McHugh TL, Saykin AJ, Wishart HA, Flashman LA, Cleavinger HB, Rabin LA, Mamourian AC, Shen L. Hippocampal volume and shape analysis in an older adult population. TCN. (2007, in press) 

Positions/Honors/Support

2006 - present Editor-in-Chief of Brain Imaging and Behavior, Springer
2006 - 2009 Elected to the Board of Governors of the International Neuropsychological Society
2002 - 2007 Elected to the Board of Directors of the American Board of Clinical Neuropsychology
1999 Neuroscience Education and Research Foundation Award for Alzheimer's Research