Commercial Library:

• This collection consists of a total of about 170,000 compounds obtained from ChemDiv (Chemical Diversity Labs, Inc.), and ChemBridge (ChemBridge Corporation)
• They are structurally diverse, pharmacophore-rich collections of drug-like small molecules
• Compounds generally obey Lipinski’s “rule of five” and demonstrate good ADME (absorption, distribution, metabolism and excretion) profiles
• Purity of the compounds is typically greater than 90%

All the library compounds were dissolved in DMSO and diluted in water, and were formatted in 384 well plates ready for screen.

NCI Libraries: NCI01 and NCI 02

• The NCI01 library consists of 1,990 compounds selected from the NCI open collection of 140,00 compounds
• Compounds were selected based upon drug-likeness
• Library includes a challenge set of 57 compounds
• Novel structural types show unusual patterns of cell line sensitivity and resistance
• The NCI02 library consists of 879 compounds representing structural diversity

For more information about these libraries: Developmental Therapeutics Program at the NCI.

Compound collection is an on-going process, and new compounds will be added to our collection from both in-house synthesis and commercial acquisition.