Dr. Hess

Jay L. Hess, M.D., Ph.D., M.H.S.A.
IU School of Medicine
VP for University Clinical Affairs

Contact via Karin Davis
Phone: 317-278-0318


Jay L. Hess M.D., Ph.D., M.H.S.A. became Dean of the School of Medicine and Vice President for University Clinical Affairs at Indiana University on September 1, 2013.

As Dean, Dr. Hess administers the School of Medicine, which has nine campuses across the State of Indiana. The school includes about 1,500 full time faculty and more than 2,200 physicians who serve as volunteer faculty. The School admits about 325 students per year and is one of the largest medical schools in the US.

Dr. Hess is a native of Southport, Connecticut. He received a B.A. in Biophysics from Johns Hopkins University, M.D. and Ph.D. degrees from the Johns Hopkins University School of Medicine, a Certificate in Business Administration from The Wharton School of the University of Pennsylvania, and an M.H.S.A. degree from the University of Michigan School of Public Health. He completed residency training in Anatomic Pathology and fellowships in Hematopathology and Surgical Pathology at Brigham and Women's Hospital. 

Before moving to Indiana, Dr. Hess served for eight years as the Carl V. Weller Professor and Chair of the Department of Pathology and Professor of Pathology and Internal Medicine at the University of Michigan. Prior to his position as Chair, he served as Director of Hematopathology at the University of Pennsylvania and as Assistant Professor of Pathology at Washington University School of Medicine.

A board-certified Hematopathologist and author of over 100 scientific papers and book chapters, Dr. Hess is considered one of the nation’s leaders in the epigenetics of leukemia. His laboratory has done some of the most seminal work on the mechanisms of transformation by the mixed lineage leukemia protein MLL and its downstream targets, the HOX proteins. While Chair at Michigan, he assembled and led an interdisciplinary research team working to develop epigenetically targeted therapeutics for acute leukemia.  He continues to run an active NIH-funded research laboratory.

In 2007, Dr. Hess helped establish the Michigan Center for Translational Pathology led by Dr. Arul Chinnaiyan, one of the leading research centers for biomarker discovery in the nation. He created one of the first pathology informatics divisions in the nation and led the University of Michigan Health Care System strategy implementation in personalized medicine.

Dr. Hess serves on the editorial boards of a number of journals and is a member of the American Society of Clinical Investigation. In addition, in 2012, he co-founded and chaired the board of directors for Paradigm, a sequencing-based not for profit diagnostics company that provides next generation sequencing and data analysis to improve care for cancer patients. He currently chairs the Indiana University Clinical Affairs Cabinet and serves on the board of BioCrossroads, a consortium of business, industry, and academic organizations dedicated to economic development through advancements in the life sciences. He also serves on the board of the Regenstrief Institute and on the board of directors of Indiana University Health, where he chairs the Research and Education Committee.

Dr. Hess and his wife Robin have two children, Leah, a junior in high school and Andrew, who is a junior at St. Olaf College in Minnesota.

To learn more about Dr. Hess and his vision for the IU School of Medicine, please view the Spring 2014 edition of IU Medicine.

Fairbanks Hall | 340 West 10th Street, Suite 6200 | Indianapolis, IN 46202-3082 | (317) 274-8157